RNA Details
Disease Name
liver cirrhosis
Tissue
liver
RNA Symbol
SIRT2
RNA ID
RNA Type
mRNA
Alteration Pattern
histone deacetylase
Species
homo sapiens
Detection Methods
qRT-PCR; immunofluorescence; etc.
Target
SIRT2
Pathway
NA
PubMed ID
Title
Inhibition of SIRT2 suppresses hepatic fibrosis
Year
2016
Function
"Sumoylation of nrf2 and mafg enhances heterodimerization and increases gclc expression, which keeps hscs in a quiescent state. Antifibrotic agents require activation of gclc to fully exert their protective effect."